A sexta temporada tem estreia prevista nos Estados Unidos no dia 24 de Setembro de 2009. O episódio duplo começou a ser gravado a 15 de Julho de 2009.
Meredith é uma cirurgiã interna do primeiro ano no Hospital Seattle Grace, o programa cirúrgico mais rígido da Harvard. Ela e seus outros colegas internos Cristina, Izzie, George e Alex eram apenas estudantes até ontem. Hoje eles são médicos e, num mundo onde o treinamento no trabalho é uma questão de vida ou morte, todos eles tentam conciliar os altos e baixos de suas vidas pessoais.

Episódio 1: Good Mourning / Episódio 2: Goodbye
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Episódio 3: I Always Feel Like Somebody’s Watchin’ Me
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Episódio 4: Tainted Obligation
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Episódio 5: Invasion
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Episódio 6: Do You See What I See
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Episódio 7 – Give Peace a Chance:
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Episódio 8 – Invest in Love:
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Episódio 9 – New History:
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Episódio 10 – Holidaze:
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Episódio 11 – Blink:
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Episódio 12 – I Like You So Much Better When You’re Naked:
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Episódio 13 – State of Love and Trust:
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Episódio 14 – Valentine’s Day Massacre:
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Episódio 15 – The Time Warp:
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Episódio 16 – Perfect Little Accident:
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Episódio 17 – Push:
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Episódio 18 – Suicide is Painless:
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Episódio 19 – Sympathy for the Parents:
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Episódio 20 – Hook, Line and Sinner:
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Season 6, Episode 21: How Insensitive
Original Air Date—6 May 2010

Season 6, Episode 22: Shiny Happy People
Original Air Date—13 May 2010